Presented by Jenni Murray. Jenni is joined by the curator of Prints and Drawings at the British Museum, Jennifer Ramkalawon, and author Wendy Moore to discuss the changing face of marriage in Britain in the 1700s. Granta's first female editor, Alex Clark, joins Jenni to discuss the challenges of editing a magazine of new writing and to talk about the first edition under her leadership, entitled Fathers: The Men Who Made Us. There is a new wave of female acts waiting to take 2009 by storm. Jenni is joined by deputy editor of the NME, Krissi Murison, and pop critic from The Guardian, Caroline Sullivan, to discuss them. Jenni talks to Chief Executive of the Alzheimer's Research Trust, Rebecca Wood, about the discovery of the first gender-linked gene for Alzheimer's. Vera Frankl reports from Nicaragua and meets one of the families affected by the blanket ban on abortion. Including drama: Dear Mr Spectator.