Prunella Scales and Anne Reid star in this fractious festive 11th series of the Radio 4 comedy favourite Ladies of Letters. By Carole Hayman & Lou Wakefield. Irene has to hold back on her grievances with Vera's selfishness when Vera's daughter Karen has a serious health scare. Vera ..... Anne Reid Irene ..... Prunella Scales Directed by Liz Webb.