Anne McElvoy is joined by David Willetts, Shadow Secretary of State for Innovation, Universities and Skills, for a review of a new television drama about Baroness Thatcher. With Miri Rubin discussing her cultural history of one of the most complex and influential of all religious figures - the Mother of God, and an interview with Alvaro Siza, the Portuguese architect who has won the 2009 gold medal from RIBA. Plus a review of Gerhard Richter's first show at the National Portrait Gallery as well as a discussion on cruelty and its place in our lives with psychotherapist Brett Kahr and neuroscientist Kathleen Taylor.