Set in noughties Britain, Mouth to Mouth deals with six young adults as they enter their twenties and realise that there is more to status than a Facebook update. Each year-in-the-life episode concentrates on one character's story as their lives intertwine and sometimes collide. Small events have big effects and molehills become mountains, as each of them scrabble to find their way and discover that be it comic, tragic and unpredictable, modern life can be tough. Gym-loving ladies man Luke Sobers is one step away from his childhood dream of playing professional football for his local club, and when he meets legendary striker Romeo Baptiste he feels closer to the big time than ever before. But Romeo has a secret and Luke is soon embroiled in a friendship that threatens both their careers. When a road accident puts both of them in the spotlight, Luke realises that his hero is not what he seems. Faced with lying to save Romeo or exposing himself, Luke faces up to who he really is.