Best friends Hannah C and Hannah T, Abigail and Naomi, Grace and Jack, and Sam and Joseph are put through the Mixer to form new pairs of Frenemies. They have to navigate through fiendish challenges, avoiding elimination, to get to the final where the winning pair of Frenemies are reunited with their best friends to battle it out to the end. The winners take home silver Hand of Friendship medallions and the losers get a one way ticket to Clagsville.