Comedy-drama series about three twenty-something housemates trying to live normal lives, despite struggling with unusual afflictions - one is a werewolf, one is a vampire and the other is a ghost. They face a human threat in the form of the mysterious Professor Jaggat and the cold-hearted Kemp. Jaggat and Kemp are fundamentalist Christians who have discovered the existence of vampires, werewolves and ghosts - and are determined to destroy them or carry out brutal experiments upon them. They believe that vampires are the Devil incarnate and must be destroyed; that werewolves contain an evil gene that can be removed by violent scientific experiments; and that ghosts must be forced over to the other side whether they like it or not. Two strangers arrive in Bristol to torment Mitchell and George. Nina wrestles with troubles of her own, while Annie decides to get a job in the real world. George struggles to deal with his murder of Herrick.