Every year millions of people in Britain try to lose weight, and most fail. We are constantly bombarded with advice about dieting and the latest slimming fads. But what really works? In this programme, medical journalist Michael Mosley investigates the latest scientific breakthroughs in slimming, uncovering ten of the simplest ways you can shed those pounds. From the slimming secrets of soup to our brain's response after skipping meals, what he discovers may completely change the way you think about diets, health and losing weight. Michael does not look like he is at all overweight, but while making this film he discovered that he, like millions of others, has internal body fat around his kidneys and liver that he really needs to lose. So he tries out the scientific tips himself, and by the end of the film he succeeds in losing the weight he wants. Plus, musician Alex James, who is a passionate cheese maker, tries out an intriguing scientific discovery - that low-fat dairy products can help you excrete more fat from all your food. Radio presenter Amy Lame learns how just a few small changes in her daily routine can help burn significantly more calories, which is handy for those who hate exercise and the gym. And actress Debbie Chazen, who eats healthy foods, has her metabolism checked and keeps a food diary - with some surprising results. We discover the scientific reasons why soup keeps you feeling fuller for longer than solid food: it's all to do with the particular way the stomach shrinks and expands, and we'll prove it using ultrasound scans of Territorial Army recruits. Full of practical tips and scientific insights, we discover how anyone can lose weight more easily.